Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106.

@article{Julander2009ActivityOT,
  title={Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106.},
  author={Justin G Julander and Kristiina Shafer and Donald F. Smee and John D. Morrey and Yousuke Furuta},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 1},
  pages={202-9}
}
Treatment with the nucleoside analog T-1106 was previously shown to be effective in a hamster model of yellow fever virus (YFV) disease, even though it had only slight activity in cell culture. In the study described in this report, the activity of T-705, a chemically related compound currently undergoing clinical trials for the treatment of influenza (FDANews 4:1, 2007), was tested against YFV in cell culture and in the hamster model. The antiviral efficacy of T-705 in cell culture occurred at… CONTINUE READING