Activity of Serotonergic Neurons in Behaving Animals

@article{Jacobs1999ActivityOS,
  title={Activity of Serotonergic Neurons in Behaving Animals},
  author={Barry L. Jacobs and Casimir A. Fornal},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={21},
  pages={9S-15S}
}

Figures from this paper

Neuromodulatory role of serotonin in the ferret thalamus.

TLDR
The results suggest that serotonergic inputs act differentially across the thalamus in a complex manner involving direct and indirect mechanisms, and it appears that 5-HT has a greater direct postsynaptic inhibitory influence in the posterior, medial, and intralaminar nuclei than in the primary sensory nuclei.

Hypothalamic Regulation of Sleep and Arousal

TLDR
Anatomical and functional evidence supports the hypothesis that GABAergic neurons in the median preoptic nucleus (MnPN) and ventrolateral pre optic area (VLPO) exert inhibitory control over the monoaminergic systems and the hypocretin system during sleep.

Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response

Sleep/wake behavior is regulated by distinct groups of neurons, such as dopaminergic, noradrenergic, and orexinergic neurons. Although monoaminergic neurons are usually considered to be

Beyond the central pattern generator: amine modulation of decision-making neural pathways descending from the brain of the medicinal leech

TLDR
It is demonstrated that the serotonergic LL and Retzius cells in the brain are excited by swim-initiating stimuli and during spontaneous swim episodes and over time, 5-HT secretion may provide a homeostatic feedback mechanism to limit swimming activity at the level of the head brain.

The Role of Serotonin in Tritonia diomedea1

TLDR
The concept of serotonin as oscillatizer is used to explain the role of serotonergic neurons in Tritonia and how exposure to subthreshold stimuli enhanced swimming in response to a subsequent super-threshold stimulus, perhaps using a similar excitatory process.

Neuronal Circuit Dissection in the Drosophila Brain: the Role of Serotonin-Releasing Neurons in Arousal

TLDR
It is verified that two individual, serotoninergic cells of the PMP cluster are sufficient to modulate the arousal level in flies, and that this modulatory effect can be elicited from a specific subset of serotoninergic neurons in PMP down cluster.

Evolution and function in serotonergic systems.

  • R. Gillette
  • Biology
    Integrative and comparative biology
  • 2006
TLDR
Connection of nutrient storage depots to CNS circuitry mediating appetite may supply critical substrate for evolving complexity in brain and behavior.

5-HT neurons and central CO2 chemoreception

...

References

SHOWING 1-10 OF 27 REFERENCES

Lack of response of serotonergic neurons in the dorsal raphe nucleus of freely moving cats to stressful stimuli

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

  • E. LevineB. Jacobs
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
TLDR
The results indicate that iontophoretic application of the GABA antagonist bicuculline reversed the typical suppression of neuronal activity seen during slow wave sleep, but had no effect on maintained activity during wakefulness, suggesting a role for a GABAergic input to DRN-5-HT neurons in controlling some aspects of their state-dependent activity.

Single-unit responses of serotonergic neurons to glucose and insulin administration in behaving cats.

TLDR
The results indicate that the activity of serotonergic DRN neurons is unrelated to alterations in blood glucose and is not sensitive to elevations of endogenous circulating insulin levels or to exogenous insulin administration, and does not support a role in glucoregulation in the cat.

Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats

TLDR
Serotonergic caudal raphe neurons are responsive to specific motor system challenges, with many neurons responsive to multiple motor tasks, and that the responsiveness of serotonergic neurons to at least one motor task, hypercarbic ventilatory challenge, is state dependent.

Activation of Serotonergic Neurons in the Raphe Magnus Is Not Necessary for Morphine Analgesia

TLDR
Serotonin release, although neither necessary nor sufficient for opioid analgesia, is proposed to facilitate the analgesic effects of nonserotonergic RM terminals in the spinal cord.