Activity of Quinolones Against Gram-Positive Cocci: Mechanisms of Drug Action and Bacterial Resistance

@article{Schmitz2002ActivityOQ,
  title={Activity of Quinolones Against Gram-Positive Cocci: Mechanisms of Drug Action and Bacterial Resistance},
  author={F K Schmitz and Patrick Higgins and Susanne V Mayer and Ad C. Fluit and Axel A H Dalhoff},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={2002},
  volume={21},
  pages={647-659}
}
The quinolones are a potent class of antimicrobial agents that target two essential enzymes of bacterial cells: DNA gyrase and topoisomerase IV. Resistance is mediated chiefly through stepwise mutations in the genes that encode these enzymes, leading to alterations of the target site. These mutations occur in an area called the "quinolone resistance determining region". In gram-positive organisms, mutations occur more often in topoisomerase IV than in DNA gyrase. This target preference appears… CONTINUE READING