Activity of E2F-dependent promoters in bladder carcinoma cells and their use for tumour-specific targeting of p53-induced apoptosis.

@article{Steinhoff2002ActivityOE,
  title={Activity of E2F-dependent promoters in bladder carcinoma cells and their use for tumour-specific targeting of p53-induced apoptosis.},
  author={Christine Steinhoff and Andrea Prior and Gaby Reichmann and H Seifert and Wolfgang A. Schulz},
  journal={International journal of oncology},
  year={2002},
  volume={21 5},
  pages={1033-40}
}
Inactivation of P53 and RB functions are crucial changes in bladder cancer (TCC). High-level re-expression of P53 elicits apoptosis in TCC cell lines, but also--as shown here--in normal uroepithelial cells. Compromised RB function is thought to cause increased activity of E2F-dependent promoters in carcinoma cells. Indeed, several, but not all E2F-dependent promoters were stronger in TCC lines than in normal cells, with the highest activities in cell lines lacking RB rather than p16INK4A. Re… CONTINUE READING