Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells.

@article{Tajima2011ActivityOB,
  title={Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells.},
  author={Nobuyoshi Tajima and Yutaka Itokazu and Esa R Korpi and Pentti Somerharju and Reijo K{\"a}kel{\"a}},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 7},
  pages={5624-38}
}
Interaction of large conductance Ca(2+)- and voltage-activated K(+) (BK(Ca)) channels with Na(+)/K(+)-ATPase, caveolin-1, and cholesterol was studied in human melanoma IGR39 cells. Functional BK(Ca) channels were enriched in caveolin-rich and detergent-resistant membranes, i.e. rafts, and blocking of the channels by a specific BK(Ca) blocker paxilline reduced proliferation of the cells. Disruption of rafts by selective depletion of cholesterol released BK(Ca) channels from these domains with a… CONTINUE READING

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