Activity of 11β-Hydroxysteroid Dehydrogenase in the Adrenal Glands, Liver, and Kidneys of Rats with Experimental Diabetes

  title={Activity of 11$\beta$-Hydroxysteroid Dehydrogenase in the Adrenal Glands, Liver, and Kidneys of Rats with Experimental Diabetes},
  author={Olga P. Cherkasova and V. G. Selyatitskaya and N. A. Pal’chikova and Natalya V. Kuznetsova},
  journal={Bulletin of Experimental Biology and Medicine},
We studied activity of the key enzyme of the pre-receptor metabolism of glucocorticoid hormones, 11β-hydroxysteroid dehydrogenase, in rat adrenal glands, renal cortex and liver in the course of development of alloxan diabetes (9, 20, and 28 day). The enzyme activity was increased 3-4 fold in the adrenal glands throughout the experiment. At the same time, according to the adrenal gland level of corticosterone, its precursor 11-deoxycorticosterone and reversible metabolite 11… 


11β-Hydroxysteroid dehydrogenase in the rat adrenal
Levels of mRNA encoding the glucocorticoid-dependent enzyme phenylethanolamine N-methyltransferase, which catalyses the conversion of noradrenaline to adrenaline, were also significantly reduced in those rats given glycyrrhizic acid, and was more uniformly distributed over the adrenal gland.
Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning
  • B. Walker
  • Biology, Medicine
    Proceedings of the Nutrition Society
  • 2007
Data support the use of 11β-HSD1 inhibitors to lower intracellular glucocorticoid levels and treat both obesity and its metabolic complications and the non-selective ‘prototype’ inhibitor carbenoxolone enhances insulin sensitivity in human subjects.
11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action.
Here, the activation of cortisol from cortisone facilitates glucocorticoid hormone action at an autocrine level and answers a long standing conundrum relating to the set-point of 11beta-HSD1 activity.
Uninephrectomy reduces 11β-hydroxysteroid dehydrogenase type 1 and type 2 concomitantly with an increase in blood pressure in rats.
Renal allograft donors are at risk of developing hypertension. Here, we hypothesized that this risk is at least in part explained by an enhanced intracellular availability of
11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors as Promising Therapeutic Drugs for Diabetes: Status and Development
Lowering intracellular glucocorticoid concentrations through administration of small molecule 11β-HSD1 selective inhibitors, significantly attenuates the signs and symptoms of disease in preclinical animal models and clinical trials of diabetes and metabolic syndrome.
Activity of 11β-hydroxysteroid dehydrogenase in tissues of hypertensive NISAG rats
  • O. Cherkasova
  • Biology, Chemistry
    Bulletin of Experimental Biology and Medicine
  • 2006
Functional activity of 11β-hydroxysteroid dehydrogenase probably reflects the hypertensive state of NISAG rats.
Adrenocortical system activity in alloxan-resistant and alloxan-susceptible Wistar rats
In alloxan-susceptible rats, the mass index of adrenal gland is increased, and that of thymus is decreased and corticosterone concentration in blood, adrenal glands and urine as well as alanine and aspartate aminotransferase activities in liver are increased; in alloxa-resistant rats the values of these indices do not differ from those of rats of the control group.
Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans
The liver accounts for all splanchnic cortisol production in obese nondiabetic humans, and the viscera releases cortisone into the portal vein, thereby providing substrate for intrahepatic cortisol production.