Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic

@inproceedings{Nadaf2010ActivityMO,
  title={Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic},
  author={Shafagh Al Nadaf and Paul D. Waters and Edda Koina and Janine E Deakin and Kristen S Jordan and Jennifer A. Marshall Graves},
  booktitle={Genome Biology},
  year={2010}
}
X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an XIST orthologue. We examined expression of X-borne genes using quantitative PCR, revealing a range of dosage compensation for different loci. To assess the… CONTINUE READING

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