Activity losses among T4 lysozyme variants after adsorption to colloidal silica.

@article{Bower1998ActivityLA,
  title={Activity losses among T4 lysozyme variants after adsorption to colloidal silica.},
  author={C K Bower and Qiang Xu and Joseph S. Mcguire},
  journal={Biotechnology and bioengineering},
  year={1998},
  volume={58 6},
  pages={658-62}
}
Maintaining a specific molecular conformation is essential for the proper functioning of an enzyme. A substantial loss of catalytic activity can occur from the displacement caused by even a single amino acid substitution. Activity may also be lost as an enzyme undergoes a conformational change during adsorption. In this study, we investigated the effect of thermostability on the activities of three T4 lysozyme variants after adsorption to 9 nm colloidal silica particles. Less-stable T4 lysozyme… CONTINUE READING

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