Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

@article{Ehlers2003ActivityLC,
  title={Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system},
  author={Michael D. Ehlers},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={231-242}
}
Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with… CONTINUE READING
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