Activity induced changes in the distribution of Shanks at hippocampal synapses.

@article{TaoCheng2010ActivityIC,
  title={Activity induced changes in the distribution of Shanks at hippocampal synapses.},
  author={Jung-Hwa Tao-Cheng and A Dosemeci and Paul E. Gallant and Colleen Smith and Torsten Reese},
  journal={Neuroscience},
  year={2010},
  volume={168 1},
  pages={11-7}
}
Dendritic spines contain a family of abundant scaffolding proteins known as Shanks, but little is known about how their distributions might change during synaptic activity. Here, pre-embedding immunogold electron microscopy is used to localize Shanks in synapses from cultured hippocampal neurons. We find that Shanks are preferentially located at postsynaptic densities (PSDs) as well as in a filamentous network near the PSD, extending up to 120 nm from the postsynaptic membrane. Application of… CONTINUE READING
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