Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity.

  title={Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity.},
  author={Da Wei Li and Eun Bang Lee and S. Kang and J. Hyun and W. Whang},
  journal={Chemical \& pharmaceutical bulletin},
  volume={50 7},
By bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranoside (2) and pictogenin (3beta… Expand
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