Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques.


The aim of the present study was to apply an activity-guided screening procedure to coffee brew to identify a key chemopreventive compound by means of in vitro antioxidant tests as well as cell culture experiments and to prove the in vivo activity of that compound by an animal feeding experiment. Solvent fractionation, followed by multiple-step… (More)


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