Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors.

@article{Lissin1998ActivityDR,
  title={Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors.},
  author={Dmitri V. Lissin and Stephen N. Gomperts and Reed C. Carroll and Chadwick W. Christine and Daniel Kalman and Masatsugu Kitamura and Steven Hardy and Roger A Nicoll and Robert C Malenka and Mark von Zastrow},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 12},
  pages={
          7097-102
        }
}
Distinct subtypes of glutamate receptors often are colocalized at individual excitatory synapses in the mammalian brain yet appear to subserve distinct functions. To address whether neuronal activity may differentially regulate the surface expression at synapses of two specific subtypes of ionotropic glutamate receptors we epitope-tagged an AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor subunit (GluR1) and an NMDA (N-methyl-D-aspartate) receptor subunit (NR1) on their… CONTINUE READING

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Lissin et al

  • H. Dong, R. J. O’Brien, +5 authors 279–284. 7102 Neurobiology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
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