Activity-dependent synaptic plasticity of NMDA receptors.

  title={Activity-dependent synaptic plasticity of NMDA receptors.},
  author={Nelson Rebola and Bettadapura N Srikumar and Christophe Mulle},
  journal={The Journal of physiology},
  volume={588 Pt 1},
Activity-dependent, bidirectional control of synaptic efficacy is thought to contribute to many forms of experience-dependent plasticity, including learning and memory. Although most excitatory synapses contain both AMPA and N-methyl-d-aspartate receptors (AMPARs and NMDARs), most studies have focused on the plasticity of synaptic AMPARs, and on the pivotal role of NMDA receptors for its induction. Here we review evidence that synaptic NMDARs themselves are subject to long-term activity… CONTINUE READING

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