Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.

  title={Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.},
  author={Jianyong Chen and Chang Sin Park and Shao-Jun Tang},
  journal={The Journal of biological chemistry},
  volume={281 17},
Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling… CONTINUE READING
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