Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat

  title={Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat},
  author={B. Shim and M. Ringkamp and George L. Lambrinos and T. Hartke and R. A. Meyer},
  • B. Shim, M. Ringkamp, +2 authors R. A. Meyer
  • Published 2007
  • Chemistry, Medicine
  • Pain
  • Abstract Growing evidence suggests that uninjured afferents may play an important role in neuropathic pain following nerve injury. The excitability of nociceptive neurons in the L4 spinal nerve appears to be enhanced following an injury to the adjacent L5 spinal nerve. In this study, we investigated whether the action‐potential conduction properties of unlesioned, unmyelinated fibers are also altered. A teased‐fiber technique was used to record from single C fibers from the L4 spinal nerve of… CONTINUE READING
    35 Citations
    Resolution of inflammation-induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors.
    • A. Dilley, G. Bove
    • Medicine
    • The journal of pain : official journal of the American Pain Society
    • 2008
    • 48
    Local Loperamide Injection Reduces Mechanosensitivity of Rat Cutaneous, Nociceptive C-Fibers
    • 6
    • PDF


    Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers
    • 390
    • PDF
    Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey.
    • 279
    • PDF
    Activity-dependent slowing of conduction velocity provides a method for identifying different functional classes of c-fibre in the rat saphenous nerve
    • 81
    • Highly Influential
    Activity‐dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin
    • 163
    An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • 2,862
    Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    • 117
    Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain
    • 348
    • Highly Influential
    • PDF