Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat

@article{Shim2007ActivitydependentSO,
  title={Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat},
  author={Beom Jin Shim and Matthias Ringkamp and George L. Lambrinos and Timothy V. Hartke and Richard A. Meyer},
  journal={Pain},
  year={2007},
  volume={128},
  pages={40-51}
}
Growing evidence suggests that uninjured afferents may play an important role in neuropathic pain following nerve injury. The excitability of nociceptive neurons in the L4 spinal nerve appears to be enhanced following an injury to the adjacent L5 spinal nerve. In this study, we investigated whether the action-potential conduction properties of unlesioned, unmyelinated fibers are also altered. A teased-fiber technique was used to record from single C fibers from the L4 spinal nerve of the rat in… CONTINUE READING
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