Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

@inproceedings{Roberson2013ActivitydependentSR,
  title={Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons},
  author={David P. Roberson and Sagi Gudes and Jared M. Sprague and Haley A. W. Patoski and Victoria K Robson and Felix Blasl and Bo Duan and Seog Bae Oh and Bruce P. Bean and Qiufu Ma and Alexander M. Binshtok and Clifford J Woolf},
  booktitle={Nature Neuroscience},
  year={2013}
}
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. Using a strategy of reversibly silencing specific subsets of murine pruritogen-sensitive sensory axons by targeted delivery of a charged sodium-channel blocker, we found that functional blockade of histamine itch did not… CONTINUE READING
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