Activity-dependent sharpening of the regenerating retinotectal projection in goldfish: relationship to the expression of growth-associated proteins

@article{Benowitz1987ActivitydependentSO,
  title={Activity-dependent sharpening of the regenerating retinotectal projection in goldfish: relationship to the expression of growth-associated proteins},
  author={L. Benowitz and J. Schmidt},
  journal={Brain Research},
  year={1987},
  volume={417},
  pages={118-126}
}
During regeneration of the optic nerve in goldfish, manipulations that disrupt the transmission of patterned visual information, if applied within the so-called 'sensitive period', lead to the formation of a diffuse retinotopic map (Schmidt, Cell. Mol. Neurobiol., 5 (1985) 65). The present study examined: (a) whether the sensitive period (14-50 days postcrush) coincides with the period in which specific 'growth-associated proteins' are present in the regenerating optic nerve terminals; and (b… Expand
Activity‐dependent refinement in the goldfish retinotectal system is mediated by the dynamic regulation of processes withdrawal: An in vivo imaging study
TLDR
Axon branches in retinotopic positions changed by much smaller amounts than ectopic axons, but in fish with retinal tetrodotoxin impulse blockade, no systematic difference was observed as a function of tectal position. Expand
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  • J. Cook
  • Medicine, Biology
  • Brain Research
  • 1990
Axonal injury provokes well-characterized morphological changes in goldfish retinal ganglion cells. These reach a peak as the regenerating axons restore a grossly retinotopic projection map to theExpand
Changes in rapidly transported proteins associated with development of abnormal projections in the diencephalon
TLDR
Target interactions appear to influence the retinal ganglion cells' expression of different proteins in a specific fashion, including the neural cell adhesion molecule, NCAM, which is normally synthesized and transported at high levels at early stages of development and then declines during the second and third postnatal weeks. Expand
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  • J. Schmidt
  • Biology, Medicine
  • Journal of neurobiology
  • 1998
TLDR
Examination of levels of PKC in the regenerating retinotectal projection via immunostaining and assay of activity verifies that the increased staining in nerve represented an up-regulation of functional PKC during nerve regeneration. Expand
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  • J. Schmidt
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1990
TLDR
The results support the involvement of NMDA receptors in sharpening and suggest that the initial step in stabilizing appropriate branches may be a long- lasting increase in synaptic gain. Expand
Immunohistochemical localization of GAP‐43 in the developing hamster retinofugal pathway
TLDR
The high levels of GAP‐43 in embryonic and neonatal optic tract axons coincide temporally with axon elongation, initial target contact, and collateral formation by the retinofugal fibers, whereas subsequent concentration of the protein in the neuropil suggests its involvement in the elaboration of terminal arbors and synaptogenesis. Expand
Changes in rapidly transported proteins in developing hamster retinofugal axons
TLDR
Temporal correlations between the molecular changes described here and the known anatomical events in optic tract development suggest that the synthesis and transport of particular membrane proteins may be directly related to the sequence of morphological changes. Expand
Abnormal retinal projections alter GAP-43 patterns in the diencephalon
TLDR
The results show that retinal terminals induced to form in an abnormal target area undergo their normal diminution of GAP-43, and that these retinal projections displace other G AP-43-rich terminals in the LP that appear to arise from local interneurons. Expand
Alterations in geniculate ganglion proteins following fungiform receptor damage.
TLDR
Electrophoretic profiles of geniculate ganglion proteins following P2 receptor damage and late (> P40) receptor damage are examined and it is shown that proteins that were preferentially affected by P2 damage may be involved in the regulation of initial axonal growth within the lingual epithelium and NST, as opposed to the structural repair or maintenance of extant axons. Expand
Mapping the development of the rat brain by GAP-43 immunocytochemistry
TLDR
The period of dense neuropil staining coincides with the formation of axonal end-arbors, the beginning of synaptogenesis, and the time at which synaptic organization can be modified by the impingent pattern of activity (i.e. the critical period). Expand
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2-dimensional gel electrophoresis was used to analyse the effects of two different schedules of TTX treatment on incorporation of [3H]proline into individual proteins conveyed by fast axonal transport in the optic nerve, and a number of proteins showed a larger reduction as a result of the delayed treatment. Expand
Activity sharpens the map during the regeneration of the retinotectal projection in goldfish
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Blocks during various portions of the regeneration process showed that lack of activity during the process of axonal elongation does not cause enlargement of the multiunit receptive fields, but lack ofActivity during the period of synapse formation and maturation does. Expand
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TLDR
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The optic tectum regulates the transport of specific proteins in regenerating optic fibers of goldfish
The pattern of rapidly-transported proteins in regenerating optic fibers of the adult goldfish is regulated by interactions between these fibers and their main target, the optic tectum. When theExpand
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