Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.

@article{Zhang2012ActivitydependentRO,
  title={Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.},
  author={Peng Zhang and John E. Lisman},
  journal={Journal of neurophysiology},
  year={2012},
  volume={107 4},
  pages={1058-66}
}
CaMKII and PSD-95 are the two most abundant postsynaptic proteins in the postsynaptic density (PSD). Overexpression of either can dramatically increase synaptic strength and saturate long-term potentiation (LTP). To do so, CaMKII must be activated, but the same is not true for PSD-95; expressing wild-type PSD-95 is sufficient. This raises the question of whether PSD-95's effects are simply an equilibrium process [increasing the number of AMPA receptor (AMPAR) slots] or whether activity is… CONTINUE READING

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