Activity-dependent regulation of surface glucose transporter-3.

@article{Ferreira2011ActivitydependentRO,
  title={Activity-dependent regulation of surface glucose transporter-3.},
  author={Jainne M Ferreira and Arthur L. Burnett and Gerald A Rameau},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 6},
  pages={1991-9}
}
Glucose transporter 3 (GLUT3) is the main facilitative glucose transporter in neurons. Glucose provides neurons with a critical energy source for neuronal activity. However, the mechanism by which neuronal activity controls glucose influx via GLUT3 is unknown. We investigated the influence of synaptic stimulation on GLUT3 surface expression and glucose import in primary cultured cortical and hippocampal neurons. Synaptic activity increased surface expression of GLUT3 leading to an elevation of… CONTINUE READING

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