Activity-dependent regulation of inhibitory synapse development by Npas4

  title={Activity-dependent regulation of inhibitory synapse development by Npas4},
  author={Yingxi Lin and Brenda L Bloodgood and Jessica L. Hauser and Ariya D. Lapan and Alex C. Koon and Tae-kyung Kim and L. Hu and A. Malik and M. Greenberg},
  • Yingxi Lin, Brenda L Bloodgood, +6 authors M. Greenberg
  • Published 2008
  • Medicine, Biology
  • Nature
  • Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (γ-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the… CONTINUE READING
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