Activity-dependent regulation of excitable axonal domains

  title={Activity-dependent regulation of excitable axonal domains},
  author={Keiichiro Susuki and Hiroshi Kuba},
  journal={The Journal of Physiological Sciences},
  • K. Susuki, H. Kuba
  • Published 1 March 2016
  • Chemistry, Medicine
  • The Journal of Physiological Sciences
Rapid action potential propagation along myelinated axons requires voltage-gated Na+ channel clustering at the axon initial segments (AISs) and nodes of Ranvier. The AIS is intrinsically defined by cytoskeletal proteins expressed in axons, whereas nodes of Ranvier are formed by interaction between neurons and myelinating glia. These axonal domains have long been considered stable structures, but recent studies revealed that they are plastic and contribute to fine adjustment of neuronal… 
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