Activity-dependent polyadenylation in neurons.

@article{Du2005ActivitydependentPI,
  title={Activity-dependent polyadenylation in neurons.},
  author={Ling Zhi Du and Joel D. Richter},
  journal={RNA},
  year={2005},
  volume={11 9},
  pages={
          1340-7
        }
}
Activity-dependent changes in protein synthesis modify synaptic efficacy. One mechanism that regulates mRNA translation in the synapto-dendritic compartment is cytoplasmic polyadenylation, a process controlled by CPEB, the cytoplasmic polyadenylation element (CPE)-specific RNA binding protein. In neurons, very few mRNAs are known CPEB substrates, and none appear to be responsible for the effects on plasticity that are found in the CPEB knockout mouse. These results suggest that the translation… CONTINUE READING

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