Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5.

@article{Cerda2011ActivitydependentPO,
  title={Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5.},
  author={Oscar A Cerda and James S Trimmer},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 33},
  pages={28738-48}
}
Dynamic modulation of ion channel expression, localization, and/or function drives plasticity in intrinsic neuronal excitability. Voltage-gated Kv2.1 potassium channels are constitutively maintained in a highly phosphorylated state in neurons. Increased neuronal activity triggers rapid calcineurin-dependent dephosphorylation, loss of channel clustering, and hyperpolarizing shifts in voltage-dependent activation that homeostatically suppress neuronal excitability. These changes are reversible… CONTINUE READING
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