Activity-dependent peptidergic modulation of the plateau-generating neuron B64 in the feeding network of Aplysia.

@article{Koh2007ActivitydependentPM,
  title={Activity-dependent peptidergic modulation of the plateau-generating neuron B64 in the feeding network of Aplysia.},
  author={H Y Koh and Klaudiusz R. Weiss},
  journal={Journal of neurophysiology},
  year={2007},
  volume={97 2},
  pages={
          1862-7
        }
}
Many behaviors display various forms of activity-dependent plasticity. An example of such plasticity is the progressive shortening of the duration of protraction phase of feeding responses of Aplysia that occurs when feeding responses are repeatedly elicited. A similar protraction-duration shortening is observed in isolated ganglia of Aplysia when feeding-like motor programs are elicited through a prolonged stimulation of the command-like neuron CBI-2. Here, we investigate a cellular mechanism… 
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Use of the Aplysia feeding network to study repetition priming of an episodic behavior.
TLDR
This review describes experiments that have characterized cellular/molecular mechanisms that produce changes in motor activity and develops a hypothesis that postulates that changes in response magnitude are a reflection of an efficient feeding strategy.
State Dependence of Spike Timing and Neuronal Function in a Motor Pattern Generating Network
TLDR
The importance of the timing of initiation of firing in determining the functional role of a neuron is indicated and it is demonstrated that this role depends on the activity-dependent state of the network.
Peptide Cotransmitters as Dynamic, Intrinsic Modulators of Network Activity
TLDR
Early studies that related peptide release to physiological firing patterns of neurons and their implications suggest that intrinsic peptidergic modulators in the CNS are likely to exert effects that are manifested dynamically in an activity-dependent manner.
Repetition Priming of Motoneuronal Activity in a Small Motor Network: Intercellular and Intracellular Signaling
TLDR
Findings indicate that priming of B48 may be implemented by a direct peptidergic modulation of its intrinsic characteristics via a pathway that activates cAMP, and suggest that in motoneurons that are driven by concurrent excitation-inhibition, repetition priming is indirect as it is preferentially implemented via modulation of the output of CPGs.
An Input-Representing Interneuron Regulates Spike Timing and Thereby Phase Switching in a Motor Network
TLDR
A neural mechanism is identified that, in an input-dependent manner, regulates spike timing and thereby the functional role of specific neurons in the Aplysia feeding network.
Parallel Regulation of a Modulator-Activated Current via Distinct Dynamics Underlies Comodulation of Motor Circuit Output
TLDR
Comodulation of rhythmic motor activity can result from convergent activation, via distinct dynamics, of a single voltage-dependent current.
The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia
TLDR
In preparations in which priming does not occur, it is shown that ingestive activity is generated when CBI-2 and CBI-3 are coactivated, and the data suggest that dynamic changes in the configuration of activity can vary and be determined by the complement of projection neurons that trigger activity.
Feedforward Compensation Mediated by the Central and Peripheral Actions of a Single Neuropeptide Discovered Using Representational Difference Analysis
TLDR
It is shown that ATRP shortens protraction duration of CBI-2-elicited ingestive programs, suggesting a contribution of ATRP to the parametric differences between CBI-4-evoked and CBI- 2-evoke programs.
Specificity of Repetition Priming: The Role of Chemical Coding
TLDR
It is demonstrated that egestive priming is not FCAP/CP-2 mediated, and is induced by an unrelated peptide (small cardioactive peptide), which exerts PKC-mediated effects.
Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.
TLDR
This work discusses experiments that determined physiological consequences of one of the hallmark features of peptidergic modulation, its persistence, and research in the feeding system demonstrated that this persistence can change network state and play an important role in determining network output.
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