Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.

@article{Li2009ActivitydependentMO,
  title={Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.},
  author={J. Li and S. Walker and M. Fitzgerald and M. Baccei},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 4},
  pages={
          2208-19
        }
}
Tissue injury in early life can produce distinctive effects on pain processing, but little is known about the underlying neural mechanisms. Neonatal inflammation modulates excitatory synapses in spinal nociceptive circuits, but it is unclear whether this results directly from altered afferent input. Here we investigate excitatory and inhibitory synaptic transmission in the rat superficial dorsal horn following neonatal hindlimb surgical incision using in vitro patch-clamp recordings and test… Expand
Modulation of developing dorsal horn synapses by tissue injury
  • M. Baccei
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 2010
Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms
Developmental regulation of membrane excitability in rat spinal lamina I projection neurons.
Persistent changes in peripheral and spinal nociceptive processing after early tissue injury
Cortex glial cells activation, associated with lowered mechanical thresholds and motor dysfunction, persists into adulthood after neonatal pain
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