Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor.

@article{Lang2006ActivitydependentMO,
  title={Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor.},
  author={Philip M. Lang and Gila Moalem-Taylor and D. Tracey and Hugh Bostock and Peter Grafe},
  journal={Journal of neurophysiology},
  year={2006},
  volume={96 6},
  pages={2963-71}
}
Activity-dependent fluctuations in axonal excitability and changes in interspike intervals modify the conduction of trains of action potentials in unmyelinated peripheral nerve fibers. During inflammation of a nerve trunk, long stretches of axons are exposed to inflammatory mediators such as 5-hydroxytryptamine [5-HT]. In the present study, we have tested the effects of m-chlorophenylbiguanide (mCPBG), an agonist at the 5-HT(3) serotonin receptor, on activity- and potential-dependent variations… CONTINUE READING

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