Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.

@article{Flores2015ActivitydependentIS,
  title={Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.},
  author={Carmen E. Flores and Irina Nikonenko and Pablo M{\'e}ndez and Jean-Marc Fritschy and Shiva K Tyagarajan and Dominique Muller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 1},
  pages={E65-72}
}
Maintaining a proper balance between excitation and inhibition is essential for the functioning of neuronal networks. However, little is known about the mechanisms through which excitatory activity can affect inhibitory synapse plasticity. Here we used tagged gephyrin, one of the main scaffolding proteins of the postsynaptic density at GABAergic synapses, to monitor the activity-dependent adaptation of perisomatic inhibitory synapses over prolonged periods of time in hippocampal slice cultures… CONTINUE READING
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We find that learning - related activity patterns known to induce N - methyl - D - aspartate ( NMDA ) receptor - dependent long - term potentiation and transient optogenetic activation of single neurons induce within hours a robust increase in the formation and size of gephyrin - tagged clusters at inhibitory synapses identified by correlated confocal electron microscopy .
We find that learning - related activity patterns known to induce N - methyl - D - aspartate ( NMDA ) receptor - dependent long - term potentiation and transient optogenetic activation of single neurons induce within hours a robust increase in the formation and size of gephyrin - tagged clusters at inhibitory synapses identified by correlated confocal electron microscopy .
We find that learning - related activity patterns known to induce N - methyl - D - aspartate ( NMDA ) receptor - dependent long - term potentiation and transient optogenetic activation of single neurons induce within hours a robust increase in the formation and size of gephyrin - tagged clusters at inhibitory synapses identified by correlated confocal electron microscopy .
We find that learning - related activity patterns known to induce N - methyl - D - aspartate ( NMDA ) receptor - dependent long - term potentiation and transient optogenetic activation of single neurons induce within hours a robust increase in the formation and size of gephyrin - tagged clusters at inhibitory synapses identified by correlated confocal electron microscopy .
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