Activity-dependent hepatocyte growth factor expression and its role in organogenesis and cancer growth suppression.


Studies by Murphy et al. have shown that neuronal stimulation can activate immediate early genes that code for transcription factors. Recent data suggest that Ca(2+) elevation in both neuronal cytoplasmic and nuclear compartments is responsible for the coupling of synaptic excitation to gene expression. Deisseroth et al. suggest that Ca(2+) influx through L… (More)


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