Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps.

@article{Ransom2000ActivitydependentEK,
  title={Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps.},
  author={Christopher B Ransom and Bruce R Ransom and Harald Sontheimer},
  journal={The Journal of physiology},
  year={2000},
  volume={522 Pt 3},
  pages={427-42}
}
1. We measured activity-dependent changes in [K+]o with K(+)-selective microelectrodes in adult rat optic nerve, a CNS white matter tract, to investigate the factors responsible for post-stimulus recovery of [K+]o. 2. Post-stimulus recovery of [K+]o followed a double-exponential time course with an initial, fast time constant, tau fast, of 0.9 +/- 0.2 s (mean +/- S.D.) and a later, slow time constant, tau slow, of 4.2 +/- 1 s following a 1 s, 100 Hz stimulus. tau fast, but not tau slow… CONTINUE READING
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