Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond.

@article{Huang2009ActivitydependentDO,
  title={Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond.},
  author={Z. Josh Huang},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 9},
  pages={
          1881-8
        }
}
GABA-mediated synaptic inhibition is crucial in neural circuit operations. The development of GABAergic inhibitory synapses and innervation pattern in mammalian neocortex is a prolonged process, extending well into the postnatal period, and is regulated by neural activity and experience. Accumulating evidence supports the hypothesis that GABA signalling acts beyond synaptic transmission and regulates inhibitory synapse development; in other words, similar to glutamate signalling at developing… CONTINUE READING

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