Activity-dependent dendritic spine neck changes are correlated with synaptic strength.

@article{Araya2014ActivitydependentDS,
  title={Activity-dependent dendritic spine neck changes are correlated with synaptic strength.},
  author={Roberto Araya and Tim P. Vogels and Rafael Yuste},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 28},
  pages={
          E2895-904
        }
}
Most excitatory inputs in the mammalian brain are made on dendritic spines, rather than on dendritic shafts. Spines compartmentalize calcium, and this biochemical isolation can underlie input-specific synaptic plasticity, providing a raison d'etre for spines. However, recent results indicate that the spine can experience a membrane potential different from that in the parent dendrite, as though the spine neck electrically isolated the spine. Here we use two-photon calcium imaging of mouse… CONTINUE READING

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