Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

@article{Puskarjov2012ActivitydependentCO,
  title={Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.},
  author={Martin Puskarjov and Faraz Ahmad and Kai Kaila and Peter Blaesse},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 33},
  pages={11356-64}
}
The K-Cl cotransporter KCC2 plays a crucial role in neuronal chloride regulation. In mature central neurons, KCC2 is responsible for the low intracellular Cl(-) concentration ([Cl(-)](i)) that forms the basis for hyperpolarizing GABA(A) receptor-mediated responses. Fast changes in KCC2 function and expression have been observed under various physiological and pathophysiological conditions. Here, we show that the application of protein synthesis inhibitors cycloheximide and emetine to acute rat… CONTINUE READING

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