Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior

@inproceedings{Martinowich2011ActivitydependentBN,
  title={Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior},
  author={Keri Martinowich and Robert J. Schloesser and Dennisse V. Jimenez and Daniel R. Weinberger and Bai Lu},
  booktitle={Molecular Brain},
  year={2011}
}
Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been suggested, but the underlying mechanisms remain unclear. Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis. We confirmed that sleep deprivation leads to an increase in… CONTINUE READING