Activity-based protein profiling for the functional annotation of enzymes

@article{Barglow2007ActivitybasedPP,
  title={Activity-based protein profiling for the functional annotation of enzymes},
  author={Katherine T Barglow and Benjamin F Cravatt},
  journal={Nature Methods},
  year={2007},
  volume={4},
  pages={822-827}
}
Activity-based protein profiling (ABPP), the use of active site-directed chemical probes to monitor enzyme function in complex biological systems, is emerging as a powerful post-genomic technology. ABPP probes have been developed for several enzyme classes and have been used to inventory enzyme activities en masse for a range of (patho) physiological processes. By presenting specific examples, we show here that ABPP provides researchers with a distinctive set of chemical tools to embark on the… CONTINUE READING

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