Activity-based probes for protein tyrosine phosphatases.

  title={Activity-based probes for protein tyrosine phosphatases.},
  author={Sanjai Kumar and Bo Zhou and Fubo Liang and Wei-Qing Wang and Zhonghui Huang and Zhong-Yin Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 21},
Protein tyrosine phosphatases (PTPs) are involved in the regulation of many aspects of cellular activity including proliferation, differentiation, metabolism, migration, and survival. Given the large number and complexity of PTPs in cell signaling, new strategies are needed for the integrated analysis of PTPs in the whole proteome. Unfortunately, the activities of many PTPs are tightly regulated by posttranslational mechanisms, limiting the utility of standard genomics and proteomics methods… CONTINUE READING
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