Activity- and schedule-dependent interactions of paclitaxel, etoposide and hydroperoxy-ifosfamide in cisplatin-sensitive and -refractory human ovarian carcinoma cell lines.

@article{Klaassen1996ActivityAS,
  title={Activity- and schedule-dependent interactions of paclitaxel, etoposide and hydroperoxy-ifosfamide in cisplatin-sensitive and -refractory human ovarian carcinoma cell lines.},
  author={Ute Klaassen and Andreas Harstrick and Norbert Schleucher and Udo Vanhoefer and J. Schr{\"o}der and Hansjochen Wilke and Siegfried Seeber},
  journal={British Journal of Cancer},
  year={1996},
  volume={74},
  pages={224 - 228}
}
Paclitaxel has demonstrated broad clinical activity in a variety of malignancies both alone and in combination with other chemotherapeutic agents. The in vitro cytotoxicity of a 2 h exposure to paclitaxel, hydroperoxy-ifosfamide and etoposide alone, in combination and in sequence, was evaluated against established cisplatin-sensitive and cisplatin-refractory human ovarian carcinoma cell lines using isobologram analysis. The combinations of either paclitaxel-hydroperoxy-ifosfamide or paclitaxel… CONTINUE READING
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Showing 1-9 of 9 references

Phase H trial of paclitaxel in patients with progressive ovarian carcinoma after platinum based chemotherapy : A gynecologic oncology group study

  • U VANHOEFER, A HARSTRICK, H WILKE, N SCHLEUCHER, H WALLES, S SCHRODERJANDSEEBER
  • J . Clin . Oncol
  • 1995
2 Excerpts

Sequences of paclitaxel and cisplatin : a phase I and pharmacologic study

  • R SKEHANP.STORENG, D SCUDIERO, +5 authors MR KENNEYSANDBOYD
  • J . Clin . Oncol .
  • 1990

What is synergy ?

  • TC HAMILTON, KC WINKERMAANDLOUIE
  • Pharmacol . Rev .
  • 1989

Augmenta - tion of adriamycin , melphalan and cisplatin cytotoxicity in drug resistant and sensitive human ovarian carcinoma cell Lines by buthionine sulfoximine mediated glutathione depletion

  • AP JEKUNEN, RD CHRISTEN, SB SHALINSKYDRANDHOWELL
  • Biochem . Pharmacol .
  • 1985

The case for combination chemotherapy in the treatment of advanced ovarian cancer

  • AM ROGAN, TC HAMILTON, RC YOUNG, RW KLECKER, RF OZOLS
  • J . Clin . Oncol .
  • 1985

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