Activity and function of rabbit muscle-specific creatine kinase at low temperature by mutation at gly268 to asn268.

Abstract

Carp muscle-specific creatine kinase M1 isoenzyme (M1-CK) seems to have evolved to adapt to synchronized changes in body temperature and intracellular pH. When gly(268) in rabbit muscle-specific creatine kinase was substituted with asn(268) as found in carp M1-CK, the rabbit muscle-specific CK G286N mutant specific activity at pH 8.0 and 10°C was more than… (More)
DOI: 10.1016/j.cbpb.2010.11.009

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