Activity and expression of the Na+/H+ exchanger in human endothelial cells cultured in high glucose

@article{Zerbini1995ActivityAE,
  title={Activity and expression of the Na+/H+ exchanger in human endothelial cells cultured in high glucose},
  author={Gianpaolo Zerbini and Timothy Roth and Edoardo Podest{\`a} and Enrico Cagliero and Alessandro Doria and M Aurora Canessa and Mara Lorenzi},
  journal={Diabetologia},
  year={1995},
  volume={38},
  pages={785-791}
}
Establishing whether high ambient glucose affects the plasma membrane Na+/H+ exchanger is relevant to understanding the adverse effects of high glucose on cell replication and the mechanisms of the increased exchanger activity encountered in diabetic patients with nephropathy. In 8 primary and 15 first-passage isolates of human endothelial cells cultured in 30 mmol/l glucose for 8.7±2.3 and 15.8±2.3 days, respectively, we determined Na+/H+ exchanger activity and mRNA levels. Activity was… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Collagen type 4 substratum ( co 11 - 4 ) inhibits the Na + / H + exchanger ( NHE ) in OKP cells

  • J Green, O Foellmer, CR Kleeman
  • J Am Soc Nephrol
  • 1994

Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose

  • M Maiello, D Boeri
  • Diabetes
  • 1992

Similar Papers

Loading similar papers…