• Corpus ID: 51795425

Activity against Herpes Simplex Virus and cytotoxicity of Noni ( Morinda citrifolia L . ) leaf extracts

  title={Activity against Herpes Simplex Virus and cytotoxicity of Noni ( Morinda citrifolia L . ) leaf extracts},
  author={Periyasamy Selvam and Julie M. Breitenbach and John C. Drach},
Morinda citrifolia L. (Noni) is indigenous to tropical countries and also used as important traditional folk medicine. Antibacterial activities of fruit extracts of M. citrifolia were evaluated against four G+ve and nine G-ve bacteria using disc and well diffusion methods. Preliminary phytochemical screening of the fruit crude extracts revealed the presences of flavonoids, saponins, alkaloids, proteins, gums and mucilages, cardiac glycosides, and phenolics. The presence of these bioactive… 
Indian Morinda species: A review
The toxicological studies revealed that higher doses of fruit juice of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys, and M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases.


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Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
Two novel glycosides extracted from the juice of Morinda citrifolia were effective in suppressing TPA- or EGF-induced cell transformation and associated AP-1 activity and subsequent cell transformation in mouse epidermal JB6 cells.