Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

@article{Rao1997ActivityRT,
  title={Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons},
  author={A. Rao and A. Craig},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={801-812}
}
  • A. Rao, A. Craig
  • Published 1997
  • Chemistry, Medicine
  • Neuron
  • We describe here a novel effect of activity on the subcellular distribution of NMDA receptors in hippocampal neurons in culture. In spontaneously active neurons, NMDA receptors were clustered at a few synaptic and nonsynaptic sites. Chronic blockade of NMDA receptor activity induced a 380% increase in the number of NMDA receptor clusters and a shift to a more synaptic distribution. This effect was reversible. The distributions of the presynaptic marker synaptophysin, the AMPA-type glutamate… CONTINUE READING
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    References

    SHOWING 1-10 OF 107 REFERENCES
    Modulation of NMDA receptor function: implications for vertebrate neural development
    • 293
    • PDF
    The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
    • 1,668
    • PDF
    NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus
    • 639
    Cellular and subcellular localization of NMDA-R1 subunit immunoreactivity in the visual cortex of adult and neonatal rats
    • 242
    • PDF