Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

  title={Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons},
  author={A. Rao and A. Craig},
  • A. Rao, A. Craig
  • Published 1997
  • Chemistry, Medicine
  • Neuron
  • We describe here a novel effect of activity on the subcellular distribution of NMDA receptors in hippocampal neurons in culture. In spontaneously active neurons, NMDA receptors were clustered at a few synaptic and nonsynaptic sites. Chronic blockade of NMDA receptor activity induced a 380% increase in the number of NMDA receptor clusters and a shift to a more synaptic distribution. This effect was reversible. The distributions of the presynaptic marker synaptophysin, the AMPA-type glutamate… CONTINUE READING
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