Activity Map of the Escherichia coli RNA Polymerase Bridge Helix*

@article{Jovanovic2011ActivityMO,
  title={Activity Map of the Escherichia coli RNA Polymerase Bridge Helix*},
  author={M Zoran Jovanovic and Patricia C. Burrows and Daniel A Bose and Beatriz C{\'a}mara and Simone C. Wiesler and Xiaodong Zhang and Sivaramesh Wigneshweraraj and Robert O. J. Weinzierl and Martin Buck},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={14469 - 14479}
}
Transcription, the synthesis of RNA from a DNA template, is performed by multisubunit RNA polymerases (RNAPs) in all cellular organisms. The bridge helix (BH) is a distinct feature of all multisubunit RNAPs and makes direct interactions with several active site-associated mobile features implicated in the nucleotide addition cycle and RNA and DNA binding. Because the BH has been captured in both kinked and straight conformations in different crystals structures of RNAP, recently supported by… 

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