• DOI:10.1016/j.neuron.2009.04.023
Corpus ID: 18512241

Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics

@article{Bannai2009ActivityDependentTO,
  title={Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics},
  author={H. Bannai and S. L{\'e}vi and C. Schweizer and T. Inoue and T. Launey and Victor Racine and J. Sibarita and K. Mikoshiba and A. Triller},
  journal={Neuron},
  year={2009},
  volume={62},
  pages={670-682}
}

H. Bannai, S. Lévi, +6 authors A. Triller

Published 2009

Chemistry, Medicine

Neuron

An activity-dependent change in synaptic efficacy is a central tenet in learning, memory, and pathological states of neuronal excitability. The lateral diffusion dynamics of neurotransmitter receptors are one of the important parameters regulating synaptic efficacy. We report here that neuronal activity modifies diffusion properties of type-A GABA receptors (GABA(A)R) in cultured hippocampal neurons: enhanced excitatory synaptic activity decreases the cluster size of GABA(A)Rs and reduces… CONTINUE READING

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