Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII

  title={Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII},
  author={K. G. Pratt and A. Watt and L. Griffith and S. Nelson and G. Turrigiano},
  • K. G. Pratt, A. Watt, +2 authors G. Turrigiano
  • Published 2003
  • Biology, Medicine
  • Neuron
  • Competitive synaptic remodeling is an important feature of developmental plasticity, but the molecular mechanisms remain largely unknown. Calcium/calmodulin-dependent protein kinase II (CaMKII) can induce postsynaptic changes in synaptic strength. We show that postsynaptic CaMKII also generates structural synaptic rearrangements between cultured cortical neurons. Postsynaptic expression of activated CaMKII (T286D) increased the strength of transmission between pairs of pyramidal neuron by a… CONTINUE READING
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