Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII

@article{Pratt2003ActivityDependentRO,
  title={Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII},
  author={Kara G Pratt and Alanna J Watt and Leslie C. Griffith and Sacha B. Nelson and Gina G. Turrigiano},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={269-281}
}
Competitive synaptic remodeling is an important feature of developmental plasticity, but the molecular mechanisms remain largely unknown. Calcium/calmodulin-dependent protein kinase II (CaMKII) can induce postsynaptic changes in synaptic strength. We show that postsynaptic CaMKII also generates structural synaptic rearrangements between cultured cortical neurons. Postsynaptic expression of activated CaMKII (T286D) increased the strength of transmission between pairs of pyramidal neuron by a… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Activity deprivation reduces mIPSC amplitude by decreasing the number of ide-induced exocytosis from populations of hippocampal synapses

  • V. Kilman, M.C.W. van Rossum, G. G. Turrigiano
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Applicability of the coefficient of variation method for analyzing synaptic plasticity.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Critical periods for experience-dependent synaptic scaling at single hippocampal synaptic boutons

  • N. S. Desai, R. H. Cudmore, S. B. Nelson, G. G. Turrigiano
  • Nature 375, 404–408. in visual cortex. Nat. Neurosci. 5, 783–789.
  • 2002
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Plasticity of ocular dominance columns in monkey striate cortex.

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Activity deprivation reduces mIPSC amplitude by decreasing the number of ide - induced exocytosis from populations of hippocampal synapses during synaptic maturation in vitro

  • O. Sporns, S. Jenkinson, V. Kilman, M. C. W. van Rossum, G. G. Turrigiano
  • Neuroscience J . Neurosci .
  • 2002