• DOI:10.1016/S0896-6273(02)01129-7
Corpus ID: 7839933

Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia

@article{Antonov2003ActivityDependentPF,
  title={Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia},
  author={I. Antonov and I. Antonova and E. Kandel and R. Hawkins},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={135-147}
}

I. Antonov, I. Antonova, +1 author R. Hawkins

Published 2003

Psychology, Medicine

Neuron

Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual… CONTINUE READING

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