Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia

@article{Antonov2003ActivityDependentPF,
  title={Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia},
  author={I. Antonov and I. Antonova and E. Kandel and R. Hawkins},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={135-147}
}
  • I. Antonov, I. Antonova, +1 author R. Hawkins
  • Published 2003
  • Psychology, Medicine
  • Neuron
  • Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual… CONTINUE READING
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