Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia
@article{Antonov2003ActivityDependentPF, title={Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia}, author={I. Antonov and I. Antonova and E. Kandel and R. Hawkins}, journal={Neuron}, year={2003}, volume={37}, pages={135-147} }
Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual… CONTINUE READING
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References
SHOWING 1-10 OF 179 REFERENCES
Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses.
- Biology, Medicine
- Science
- 1997
- 142
The Contribution of Activity-Dependent Synaptic Plasticity to Classical Conditioning in Aplysia
- Psychology, Medicine
- The Journal of Neuroscience
- 2001
- 103
- PDF
Pairing-specific, activity-dependent presynaptic facilitation at Aplysia sensory-motor neuron synapses in isolated cell culture
- Biology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1994
- 77
- PDF
Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses
- Biology, Medicine
- Science
- 1997
- 105
Involvement of Presynaptic and Postsynaptic Mechanisms in a Cellular Analog of Classical Conditioning at AplysiaSensory-Motor Neuron Synapses in Isolated Cell Culture
- Biology, Medicine
- The Journal of Neuroscience
- 1998
- 111
- PDF
Hebbian induction of long-term potentiation of Aplysia sensorimotor synapses: partial requirement for activation of an NMDA-related receptor
- Biology, Medicine
- Proceedings of the Royal Society of London. Series B: Biological Sciences
- 1994
- 128
Hebbian synapses in hippocampus.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1986
- 498
- PDF
Activity-dependent enhancement of presynaptic facilitation provides a cellular mechanism for the temporal specificity of classical conditioning in Aplysia.
- Chemistry, Medicine
- Learning & memory
- 1994
- 33
A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
- Chemistry, Medicine
- Science
- 1983
- 586
Enhancement of sensorimotor connections by conditioning-related stimulation in Aplysia depends upon postsynaptic Ca2+.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1996
- 56
- PDF