Activity-Dependent Dendritic Release of BDNF and Biological Consequences

  title={Activity-Dependent Dendritic Release of BDNF and Biological Consequences},
  author={Nicola Kuczewski and Christophe Porcher and Volkmar Lessmann and Igor Medina and Jean-Luc Gaiarsa},
  journal={Molecular Neurobiology},
Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival… CONTINUE READING

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