Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons.

@article{Roussos2016ActivityDependentCI,
  title={Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons.},
  author={Panos Roussos and Boris Guennewig and Dominik C Kaczorowski and Guy Barry and Kristen J Brennand},
  journal={JAMA psychiatry},
  year={2016},
  volume={73 11},
  pages={1180-1188}
}
Importance Schizophrenia candidate genes participate in common molecular pathways that are regulated by activity-dependent changes in neurons. One important next step is to further our understanding on the role of activity-dependent changes of gene expression in the etiopathogenesis of schizophrenia. Objective To examine whether neuronal activity-dependent changes of gene expression are dysregulated in schizophrenia. Design, Setting, and Participants Neurons differentiated from human… CONTINUE READING

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