Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry

  title={Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry},
  author={P. Sch{\"a}tzle and M. R. Silva and R. Tas and E. Katrukha and C. Hoogenraad},
  journal={Current Biology},
  • P. Schätzle, M. R. Silva, +2 authors C. Hoogenraad
  • Published 2018
  • Biology, Medicine
  • Current Biology
  • In neurons, microtubules form dense bundles and run along the length of axons and dendrites. Occasionally, dendritic microtubules can grow from the shaft directly into dendritic spines. Microtubules target dendritic spines that are undergoing activity-dependent changes, but the mechanism by which microtubules enter spines has remained poorly understood. Using live-cell imaging, high-resolution microscopy, and local glutamate uncaging, we show that local actin remodeling at the base of a spine… CONTINUE READING
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