• DOI:10.1016/j.cub.2018.05.004
Corpus ID: 49271034

Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry

@article{Schtzle2018ActivityDependentAR,
  title={Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry},
  author={P. Sch{\"a}tzle and M. R. Silva and R. Tas and E. Katrukha and C. Hoogenraad},
  journal={Current Biology},
  year={2018},
  volume={28},
  pages={2081-2093.e6}
}

P. Schätzle, M. R. Silva, +2 authors C. Hoogenraad

Published 2018

Biology, Medicine

Current Biology

In neurons, microtubules form dense bundles and run along the length of axons and dendrites. Occasionally, dendritic microtubules can grow from the shaft directly into dendritic spines. Microtubules target dendritic spines that are undergoing activity-dependent changes, but the mechanism by which microtubules enter spines has remained poorly understood. Using live-cell imaging, high-resolution microscopy, and local glutamate uncaging, we show that local actin remodeling at the base of a spine… CONTINUE READING

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