Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses

  title={Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses},
  author={Alanna J Watt and Mark C. W. van Rossum and Katrina M. MacLeod and Sacha B. Nelson and Gina G. Turrigiano},
AMPA and NMDA receptors are coexpressed at many central synapses, but the factors that control the ratio of these two receptors are not well understood. We recorded mixed miniature or evoked synaptic currents arising from coactivation of AMPA and NMDA receptors and found that long-lasting changes in activity scaled both currents up and down proportionally through changes in the number of postsynaptic receptors. The ratio of NMDA to AMPA current was similar at different synapses onto the same… CONTINUE READING
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