Activity‐dependent Refinement of Inhibitory Connections

@article{Sanes1993ActivitydependentRO,
  title={Activity‐dependent Refinement of Inhibitory Connections},
  author={Dan H. Sanes and Christiane Takacs},
  journal={European Journal of Neuroscience},
  year={1993},
  volume={5}
}
  • D. Sanes, C. Takacs
  • Published 1 June 1993
  • Biology, Medicine
  • European Journal of Neuroscience
Several lines of evidence suggest that excitatory synaptic transmission contributes to the maturation of precise neuronal connections. In the present study we determined whether the specific innervation pattern of single inhibitory arborizations was dependent upon neuronal activity during development. A homogeneous group of glycinergic inhibitory neurons in the central auditory system, the medial nucleus of the trapezoid body (MNTB), was functionally denervated in neonatal gerbils. The… Expand
REFINEMENT OF INHIBITORY CIRCUITS DURING DEVELOPMENT OF THE MAMMALIAN AUDITORY BRAINSTEM
Establishing precise neuronal connections is crucial for normal brain function. In many parts of the brain, this is accomplished by refining initially diffuse neuronal connections during development.Expand
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TLDR
Examining the development of functional connectivity before hearing onset in rats in the tonotopically organized, glycinergic pathway from the medial nucleus of the trapezoid body to the lateral superior olive found that LSO neurons became functionally disconnected from their initial inputs, resulting in a two-fold sharpening of functional topography. Expand
Spatial distribution of inhibitory synaptic connections during development of ferret primary visual cortex
TLDR
The results show a refinement and clustering in the spatial pattern of inhibitory connections during postnatal development of ferret visual cortex. Expand
Long-Lasting Inhibitory Synaptic Depression is Age- and Calcium-Dependent
TLDR
It is proposed that activity-dependent synaptic depression may support the developmental rearrangement of inhibitory terminals as they compete with neighboring excitatory and/or inhibitory inputs. Expand
Development and influence of inhibition in the lateral superior olivary nucleus
TLDR
Findings suggest that there are two phases inhibitory transmission, during an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO and during a second hyperpolarized phase there is refinement of inhibitory afferent arborizations and theLSO dendrites that they innervate. Expand
Developmental expression of inhibitory synaptic long-term potentiation in the lateral superior olive
TLDR
iLTP may support stabilization of un-pruned MNTB connections and contribute to the emergence of ILD processing in the mature LSO, and suggest a developmental period during which the induction of iLTP depends on the conjoint activation of GABAB receptors and postsynaptic depolarization. Expand
Developmental influence of glycinergic transmission: regulation of NMDA receptor-mediated EPSPs
  • V. Kotak, D. Sanes
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
TLDR
The results suggest that spontaneous glycinergic transmission influences the development of postsynaptic properties, including the IPSP reversal potential, NMDA receptor function, and a Ca2+ conductance. Expand
Gain adjustment of inhibitory synapses in the auditory system
TLDR
Recordings from LSO neurons in brain slices from developing gerbils show robust long-term depression of the MNTB-evoked IPSP/Cs when the M NTB was activated at a low frequency, and preliminary evidence also indicated strengthening of inhibitory transmission (LTP) by a distinct pattern of inhibition activity. Expand
Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive.
TLDR
Three key postsynaptic kinases, CaMKII, PKC, and PKA, participate in the activity-dependent depression of inhibitory MNTB-LSO synapses during postnatal development. Expand
The Developmental Influence of Inhibitory Synaptic Transmission
TLDR
Experimental findings from a developing inhibitory projection in the auditory system are summarized, and evidence that inhibitory transmission plays an active role during ontogeny is provided. Expand
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